The coronavirus pandemic initially manifested itself in the United States in "blue" (Democratic) districts - especially inner-city New York. Some pundits have offered that fact as a reason for the then-Republican administration's slow response to the pandemic. Skipping forward a year we find a quite different demographic pattern.
And as a result, current mortalilty rates from Covid are substantially higher in "red" states:
At the New York Times source, the data is broken down to the county level, where the differences are even more stark. And it's getting worse:
There's additional discussion and graphs at the Gallup organization website. They note that a large percentage of Americans frankly do not understand the risks of disease vs. vaccination.
Updated to add this graph (discussed here):