Ivermectin and coronavirus

I first heard about this from a BBC science podcast; a Guardian article provides more details.

The efficacy of a drug being promoted by rightwing figures worldwide for treating Covid-19 is in serious doubt after a major study suggesting the treatment is effective against the virus was withdrawn due to “ethical concerns”...

It appeared that the authors had run entire paragraphs from press releases and websites about ivermectin and Covid-19 through a thesaurus to change key words. “Humorously, this led to them changing ‘severe acute respiratory syndrome’ to ‘extreme intense respiratory syndrome’ on one occasion,” Lawrence said.

“In their paper, the authors claim that four out of 100 patients died in their standard treatment group for mild and moderate Covid-19,” Lawrence said. “According to the original data, the number was 0, the same as the ivermectin treatment group. In their ivermectin treatment group for severe Covid-19, the authors claim two patients died, but the number in their raw data is four.”

“The main error is that at least 79 of the patient records are obvious clones of other records,” Brown told the Guardian. “It’s certainly the hardest to explain away as innocent error, especially since the clones aren’t even pure copies. There are signs that they have tried to change one or two fields to make them look more natural.”

Meyerowitz-Katz told the Guardian that “this is one of the biggest ivermectin studies out there”, and it appeared to him the data was “just totally faked”. This was concerning because two meta-analyses of ivermectin for treating Covid-19 had included the Elgazzar study in the results. A meta-analysis is a statistical analysis that combines the results of multiple scientific studies to determine what the overall scientific literature has found about a treatment or intervention...

“Thousands of highly educated scientists, doctors, pharmacists, and at least four major medicines regulators missed a fraud so apparent that it might as well have come with a flashing neon sign. That this all happened amid an ongoing global health crisis of epic proportions is all the more terrifying.”

The BBC podcast pointed out that the correlary tragedy is that ivermectin does have therapeutic efficacy against some parasitic diseases, but as a result of this covid craziness, the drug is now unavailable for those uses.  And those meta-analyses need to be retracted and recalculated.

Addendum: 

"A Butler County judge ruled in favor of a woman last week who sought to force a hospital to administer Ivermectin — an animal dewormer that federal regulators have warned against using in COVID-19 patients — to her husband after several weeks in the ICU with the disease.

Butler County Common Pleas Judge Gregory Howard ordered West Chester Hospital, part of the University of Cincinnati network, to treat Jeffrey Smith, 51, with Ivermectin. The order, filed Aug. 23, compels the hospital to provide Smith with 30mg of Ivermectin daily for three weeks...

Julie Smith found Ivermectin on her own and connected with Dr. Fred Wagshul, an Ohio physician who her lawsuit identifies as “one of the foremost experts on using Ivermectin in treating COVID-19.” He prescribed the drug, and the hospital refused to administer it...

In an interview, Wagshul said the science behind Ivermectin’s use in COVID-19 patients is “irrefutable.” The CDC and FDA engaged in a “conspiracy,” he said, to block its use to protect the FDA’s emergency use authorization for COVID-19 vaccines. He said the mainstream media and social media companies have been engaging in “censorship” on Ivermectin’s merits, and that the U.S. government’s refusal to acknowledge its benefits amounts to genocide..."