Michaelangelo's depiction of breast cancer

"The unusual appearance of the left breast of Michelangelo's “Night,” a marble statue of a female figure, has often been mentioned in the literature on Michelangelo's Medici Chapel (Church of San Lorenzo, Florence, Italy). One of us, an oncologist, found three abnormalities associated with locally advanced cancer in the left breast. There is an obvious, large bulge to the breast contour medial to the nipple; a swollen nipple–areola complex; and an area of skin retraction just lateral to the nipple. These features indicate a tumor just medial to the nipple, involving either the nipple itself or the lymphatics just deep to the nipple and causing tethering and retraction of the skin on the opposite side. These findings do not appear in the right breast of “Night” or in “Dawn,” another female figure in the Medici Chapel, or in the many other depictions of women in works by Michelangelo...

Given that Michelangelo depicted a lump in only one breast, he presumably recognized this as an anomaly. Many doctors in his day could probably diagnose this condition in a woman. Historians of breast cancer agree that the disease and its treatment were discussed, often at length, and described as cancer by the most famous medical authorities of antiquity — Hippocrates, Celsus, and Galen — and by several prominent medieval authors, including Avicenna and Rolando da Parma...

Additional discussion at The New England Journal of Medicine