tag:blogger.com,1999:blog-4912713243046142041.post1219210223773143387..comments2024-03-28T12:17:44.126-05:00Comments on TYWKIWDBI ("Tai-Wiki-Widbee"): Prophylactic thyroidectomyMinnesotastanhttp://www.blogger.com/profile/01382888179579245181noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-4912713243046142041.post-17329167166655694592013-05-06T13:17:18.723-05:002013-05-06T13:17:18.723-05:00Well to be precise, it's not a "MEN2A gen...Well to be precise, it's not a "MEN2A gene" but rather a "MEN2A mutation of gene RET". Normally, cancer requires several mutations to develop, and if you happen inherit just one of them, you would be given an estimated chance of developing cancer (= acquiring the other mutations) drawn up from medical histories of others who have the same mutation. Here however, the one mutation is enough to cause cancer: if you inherit RET-MEN2A, you're essentially born with a cancer waiting to happen. <br /><br />The reason why you don't see this sort of thing more often is that having all the genetics required for cancer in place is not exactly conductive to normal development - I'd imagine that most such combinations end up in the 60% or so of fertilizations that never result in pregnancy. RET-MEN2A is more of an exception because it causes cancer only in specific tissues (endocrine glands) and therefore allows normal development even into adulthood.bucaneerhttps://www.blogger.com/profile/05630311295205545919noreply@blogger.comtag:blogger.com,1999:blog-4912713243046142041.post-45440464352550491732013-05-06T10:58:55.152-05:002013-05-06T10:58:55.152-05:00I knew that they could identify genes that marked ...I knew that they could identify genes that marked a possibility for certain conditions. I did not know they had narrowed one down to "We are 100% sure that this gene will cause you to have cancer." That is amazing.Brad Williamshttps://www.blogger.com/profile/00197301845256854051noreply@blogger.comtag:blogger.com,1999:blog-4912713243046142041.post-73267474876781614532013-05-06T10:16:11.526-05:002013-05-06T10:16:11.526-05:00Wow. I did not even know that such a gene existed....Wow. I did not even know that such a gene existed. Thanks for sharing.Brad Williamshttps://www.blogger.com/profile/00197301845256854051noreply@blogger.com